The presence of the FUS-DDIT3 fusion gene has significant clinical implications. It is a defining feature of myxoid liposarcoma, a type of soft tissue sarcoma. The identification of this fusion gene helps in the differential diagnosis of liposarcomas and other soft tissue tumors. Additionally, it has prognostic value, as tumors with the FUS-DDIT3 fusion gene tend to have a specific pattern of metastasis and response to therapy.