Dysregulation of Apaf-1 is implicated in various diseases. In cancer, reduced Apaf-1 expression or function can contribute to the resistance of tumor cells to apoptosis, thereby promoting tumor survival and growth. Conversely, in neurodegenerative diseases, increased Apaf-1 activity can lead to excessive neuronal cell death. Understanding the role of Apaf-1 in these conditions can aid in the development of targeted therapies. For example, restoring Apaf-1 function in cancer cells can potentially sensitize them to apoptosis-inducing treatments.
