Apaf-1 is ubiquitously expressed in various tissues but is particularly abundant in tissues with high rates of cell turnover, such as the immune system, gastrointestinal tract, and skin. Its expression levels can vary depending on the developmental stage and the cellular context. In histological studies, the localization and quantification of Apaf-1 expression can be assessed using techniques like immunohistochemistry and in situ hybridization.
