What Are the Challenges in Using Histology for Monitoring Treatment Response?
Despite its advantages, histology faces several challenges in monitoring treatment response:
Sampling bias: Tissue samples may not represent the entire lesion or disease process, leading to inaccurate assessments. Interobserver variability: Different pathologists may interpret histological findings differently, affecting the consistency of results. Technical artifacts: Sample preparation and staining procedures can introduce artifacts that complicate interpretation. Limited sensitivity: Some histological changes may be subtle and difficult to detect, especially in early stages of treatment.
