What Are the Challenges in Using Histology for Adjuvant Therapy?
Despite its importance, using histology to guide adjuvant therapy comes with challenges:
- Heterogeneity: Tumors can be heterogeneous, meaning different parts of the tumor may have different histological characteristics, complicating treatment decisions. - Interobserver Variability: The interpretation of histological features can vary between pathologists, potentially affecting treatment decisions. - Evolving Biomarkers: As new biomarkers are discovered, histological techniques must evolve to incorporate these new findings into clinical practice.
