What Histological Features Influence Adjuvant Therapy?
Several histological features can influence the choice and necessity of adjuvant therapy:
- Tumor Grade: Indicates how much the tumor cells resemble normal cells. High-grade tumors are more aggressive and may require more intensive adjuvant therapy. - Lymphovascular Invasion: The presence of cancer cells in the blood vessels or lymphatics suggests a higher risk of metastasis, indicating the need for adjuvant therapy. - Margins: The status of the surgical margins (whether cancer cells are present at the edge of the removed tissue) can indicate whether additional treatment is needed to eliminate residual cancer cells. - Molecular Markers: The presence of specific proteins, such as HER2 in breast cancer, can guide targeted adjuvant therapies.
