What are the Therapeutic Implications of Targeting PDGFR?
Given its critical role in various diseases, PDGFR is targeted by several therapeutic agents. Tyrosine kinase inhibitors (TKIs) such as imatinib and sunitinib have been developed to inhibit PDGFR signaling. These inhibitors are used in the treatment of certain cancers and fibrotic diseases. Research is ongoing to develop more specific and effective PDGFR inhibitors.