What are the Challenges in Developing Histology-Based Therapies?
Developing therapies based on histological targets involves several challenges:
Specificity: Ensuring that the therapy specifically targets diseased cells without affecting normal cells is crucial to minimize side effects. Delivery: Efficiently delivering the therapeutic agents to the target cells or tissues is a significant challenge, especially for large molecules like antibodies or nucleic acids. Resistance: Cells can develop resistance to therapies over time, necessitating the need for combination therapies or novel treatment approaches. Heterogeneity: Tissues are composed of different cell types with varying responses to therapy. Understanding and addressing this cellular heterogeneity is essential for effective treatment.
