BMP signaling is vital in various tissues and cellular contexts:
- Bone and Cartilage: BMPs were initially discovered for their ability to induce bone formation. They are critical in the differentiation of mesenchymal stem cells into osteoblasts and chondrocytes. - Nervous System: BMPs play roles in neural development, including the differentiation of neural progenitor cells. - Kidney: BMP signaling is involved in nephron development, influencing kidney morphogenesis. - Liver and Lungs: BMPs contribute to the development and regeneration of liver and lung tissues.
