Metabolic activity in cells and tissues can be measured using various histological techniques. Histochemistry involves the use of chemical reactions to visualize specific enzymes or metabolic products within tissue sections. Immunohistochemistry utilizes antibodies to detect proteins involved in metabolic pathways, allowing for precise localization within the tissue. Additionally, techniques such as autoradiography can track the incorporation of radioactive substrates into metabolic products, providing insight into the dynamics of cellular metabolism.