Hyaluronan synthases (HAS) are a group of enzymes responsible for the synthesis of hyaluronan, a critical component of the extracellular matrix (ECM). These enzymes catalyze the polymerization of hyaluronan by adding repeating disaccharide units of glucuronic acid and N-acetylglucosamine. In histology, hyaluronan plays a pivotal role in tissue hydration, elasticity, and cellular signaling.
