Histological grading involves assessing how much cancer cells differ from normal cells. This grading helps in predicting the aggressiveness of the tumor. Tumors are often graded on a scale (Grade 1 to Grade 3 or 4) based on the degree of differentiation and proliferative activity. Well-differentiated tumors (low grade) resemble normal tissue and are less aggressive, while poorly differentiated tumors (high grade) are more aggressive and have a worse prognosis.
