Differentiating overlapping histological features often requires a combination of techniques and considerations:
Contextual clinical information: Patient history and clinical symptoms can provide crucial context that aids in the histological interpretation. Advanced staining techniques: Immunohistochemistry and special stains can help identify specific cell types or proteins that are unique to certain conditions. Morphological details: Careful examination of cell size, shape, and arrangement can provide additional clues. For example, the presence of specific nuclear features may distinguish between reactive and neoplastic processes.
