Diagnosis of TB through histology involves examining tissue samples under a microscope. Common methods include: - Ziehl-Neelsen stain: This special staining technique is used to identify acid-fast bacilli, which are indicative of Mycobacterium tuberculosis. - Hematoxylin and Eosin (H&E) stain: This general staining method highlights the granuloma structure and caseous necrosis. - Immunohistochemistry: Antibodies specific to mycobacterial antigens can be used to detect the presence of the bacteria.