The citric acid cycle is tightly regulated to meet the energy demands of the cell. Key regulatory enzymes include citrate synthase, isocitrate dehydrogenase, and α-ketoglutarate dehydrogenase. These enzymes are regulated by various factors, including the availability of substrates, feedback inhibition by cycle intermediates, and allosteric regulation by ATP and ADP levels. Proper regulation ensures efficient energy production and metabolic flexibility.
