How Does the Citric Acid Cycle Relate to Histology?

Histologists study the structure and function of tissues, and the citric acid cycle is fundamental to tissue metabolism and energy homeostasis. For example, in highly metabolic tissues like the liver and heart, the citric acid cycle is particularly active, ensuring a constant supply of ATP. Abnormalities in the cycle can lead to metabolic disorders and tissue dysfunction, which can be observed histologically as changes in cellular morphology and staining patterns.