How is Reduced Synaptic Density Detected in Histology?
Histological techniques are pivotal for detecting changes in synaptic density. Common methods include immunohistochemistry using antibodies against synaptic markers like synaptophysin and PSD-95, electron microscopy for ultrastructural analysis, and advanced imaging techniques like confocal microscopy. These methods allow for the visualization and quantification of synapses in tissue samples.
