Glutamate Decarboxylase (GAD) is an enzyme responsible for converting the neurotransmitter glutamate into gamma-aminobutyric acid (GABA). GABA is the primary inhibitory neurotransmitter in the mammalian central nervous system (CNS). There are two isoforms of GAD: GAD65 and GAD67, named based on their molecular weights of 65 kDa and 67 kDa respectively.