Pleomorphism is typically evaluated using histological staining techniques and microscopic examination. Hematoxylin and Eosin (H&E) staining is one of the most commonly used methods to highlight cellular and nuclear details. Pathologists assess pleomorphism by examining tissue samples for the following features:
Variation in cell size and shape Irregular nuclear contours Abnormal nuclear-cytoplasmic ratio Presence of multinucleated cells
