Histological detection of p53 can be performed using immunohistochemistry (IHC), which involves the use of specific antibodies that bind to the p53 protein. By applying these antibodies to tissue sections, researchers can visualize the presence and localization of p53 under a microscope. Typically, p53 is located in the cell nucleus, and its expression can be seen as a brown staining in positive cells when using chromogenic substrates.