Nicastrin is closely linked to several neurological disorders, primarily Alzheimer's disease. Mutations or dysregulation of the γ-secretase complex, including nicastrin, can lead to abnormal processing of APP, resulting in the accumulation of amyloid-beta plaques, a hallmark of Alzheimer's. Additionally, defects in Notch signaling due to dysfunctional nicastrin can result in developmental abnormalities and certain cancers.
