Low grade squamous intraepithelial lesion (LSIL) is a term used to describe mild abnormalities in the squamous cells of the cervix. These changes are generally considered to be early and usually transient manifestations of [human papillomavirus (HPV)]() infection, specifically low-risk types. LSIL is commonly discovered during routine [Pap smear]() tests and is classified under the Bethesda system for reporting cervical cytology.