How is Mitochondrial Dysfunction Detected in Histology?
In histology, mitochondrial dysfunction can be detected using various staining techniques and electron microscopy. Histochemical stains like modified Gomori trichrome can highlight abnormal mitochondrial accumulations. Immunohistochemistry can be employed to detect specific mitochondrial proteins. Electron microscopy provides detailed images, revealing abnormalities in mitochondrial structure, such as swelling, loss of cristae, or the presence of paracrystalline inclusions.
