What Techniques Are Used to Study Genome Organization?
Several advanced techniques are employed to study genome organization, including:
- Fluorescence in situ hybridization (FISH): Used to visualize the location of specific DNA sequences within the nucleus. - Chromosome conformation capture (3C) and its derivatives: Techniques like Hi-C provide insights into the three-dimensional organization of the genome. - Chromatin immunoprecipitation (ChIP): Used to investigate protein-DNA interactions and histone modifications. - Electron microscopy: Offers detailed images of chromatin structure and organization at high resolution.
