The regulation of pro apoptotic factors involves a complex interplay between pro-apoptotic and anti-apoptotic proteins of the Bcl-2 family. Anti-apoptotic proteins like Bcl-2 and Bcl-xL inhibit the release of pro apoptotic factors from mitochondria, while pro-apoptotic proteins like Bax and Bak promote their release. The balance between these opposing forces determines the cell's fate.
