How is Microglial Activation Identified in Histology?
In histological studies, microglial activation can be identified through changes in cell morphology, expression of specific markers, and increased phagocytic activity. Activated microglia often transform from a ramified (branched) shape to an amoeboid (rounded) shape. Immunohistochemistry techniques are commonly used to detect markers such as Iba1, CD68, and MHC-II, which are upregulated during activation.
