GATA4 activity is regulated at multiple levels, including transcriptional, post-transcriptional, and post-translational mechanisms. Key regulatory pathways include:
Signaling pathways, such as the BMP and Wnt pathways, which influence GATA4 expression and activity. Post-translational modifications, including phosphorylation, acetylation, and ubiquitination, which affect GATA4's stability and function. Interactions with other transcription factors and cofactors, which modulate its binding to target DNA sequences.
