ferric reductase

How is Ferric Reductase Regulated?

The expression and activity of ferric reductase are tightly regulated by the body's iron status. When iron levels are low, the expression of ferric reductase increases to enhance iron absorption. Conversely, when iron levels are high, the expression of ferric reductase is downregulated to prevent excessive iron accumulation. This regulation is mediated by various factors, including hypoxia-inducible factors (HIFs) and the iron regulatory protein (IRP) system.

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