The expression of cyclin E is tightly controlled at multiple levels, including transcriptional, post-transcriptional, and post-translational mechanisms. Transcription factors such as E2F and AP-1 can promote the transcription of cyclin E. Additionally, the protein is subject to ubiquitin-mediated degradation by the SCF ubiquitin ligase complex, ensuring its levels decrease as the cell progresses through the S phase.
