The primary function of Ankyrin 1 is to connect integral membrane proteins, such as the anion exchanger 1 (AE1 or Band 3), to the spectrin-actin cytoskeleton network. This connection is vital for maintaining the biconcave shape of erythrocytes, which optimizes their gas exchange capabilities. In muscle cells, Ankyrin 1 helps in organizing ion channels and maintaining the structural integrity of the muscle fiber.
