How Does Tissue Heterogeneity Affect Diagnostic Approaches?
Diagnostic approaches must account for tissue heterogeneity to ensure accuracy: 1. Biopsy Sampling: Adequate sampling is crucial to capture the full spectrum of cellular diversity within a tissue. 2. Molecular Profiling: Comprehensive profiling of tissues at the molecular level can help in identifying specific biomarkers associated with different cellular subpopulations. 3. Imaging Techniques: Advanced imaging techniques, such as multiphoton microscopy, can provide detailed information about the spatial organization of cells and ECM components.
