In diseases, the normal composition of tissues can be altered. For example:
Cancer: Abnormal cell proliferation leads to changes in tissue architecture and the presence of malignant cells. Fibrosis: Excessive deposition of ECM components like collagen alters tissue structure and function, often seen in chronic inflammatory conditions. Degenerative Diseases: Loss of specific cell types or structural components, such as the degeneration of neurons in Alzheimer's disease, affects tissue integrity and function.
