Upon infection, trematodes induce various histopathological changes in host tissues. The response can range from mild inflammation to severe tissue damage. For instance, schistosomiasis caused by Schistosoma species leads to granuloma formation around the eggs deposited in tissues. These granulomas consist of immune cells, including macrophages, eosinophils, and lymphocytes, which aggregate to wall off the eggs, causing fibrosis and organ dysfunction.
