How does the inflammation phase contribute to wound healing?
The inflammation phase begins shortly after injury and is marked by the infiltration of immune cells, such as neutrophils and macrophages. Neutrophils are the first responders, clearing debris and pathogens through phagocytosis. They are soon followed by macrophages, which continue the clean-up process and release growth factors that are critical for the next phase of healing. Histologically, this phase is characterized by edema, increased vascular permeability, and the presence of inflammatory cells.