The proliferation phase is where the bulk of tissue repair occurs. It involves re-epithelialization, angiogenesis, formation of granulation tissue, and collagen deposition. Keratinocytes migrate to cover the wound, while fibroblasts synthesize collagen and extracellular matrix to provide structural support. New blood vessels form through angiogenesis to supply nutrients and oxygen to the healing tissue. Histologically, this phase is identified by the presence of granulation tissue, characterized by new capillaries, fibroblasts, and a provisional extracellular matrix.
