How Do Protein Metabolism Disorders Affect Tissues?
These disorders often lead to the accumulation of abnormal proteins or amino acids, causing cellular damage and tissue dysfunction. For example, in phenylketonuria (PKU), the lack of the enzyme phenylalanine hydroxylase leads to the buildup of phenylalanine, which can cause neuronal damage. Histologically, this might be observed as changes in brain tissue morphology and cellular architecture.
