How Does the Granular Component Impact Ribosome Biogenesis?
The efficiency and integrity of the granular component are critical for effective ribosome biogenesis. Any abnormalities or dysfunctions in the GC can lead to defects in ribosome assembly, which can subsequently impair protein synthesis. Such defects have been linked to various human diseases, including cancer and ribosomopathies, highlighting the importance of the GC in maintaining cellular homeostasis.
