Obesity-induced inflammation, also known as metaflammation, is a low-grade, chronic inflammatory state. It is initiated by the hypertrophy of adipocytes, which leads to hypoxia and subsequent cell death. This process recruits immune cells like macrophages, which secrete pro-inflammatory cytokines such as TNF-α and IL-6. These cytokines further exacerbate inflammation and contribute to systemic metabolic dysregulation.
