What are the Clinical Implications of LH3 Dysregulation?
Dysregulation of LH3 can lead to several clinical conditions: 1. Ehlers-Danlos Syndrome (EDS): Mutations in the gene encoding LH3 can cause certain types of EDS, characterized by hypermobile joints and fragile skin. 2. Fibrosis: Overexpression of LH3 has been linked to fibrotic diseases, where excessive collagen deposition leads to tissue scarring. 3. Cancer: Altered LH3 activity has been observed in various cancers, affecting tumor microenvironment and metastasis.
