The obstruction of blood flow in the microvasculature due to thrombosis results in tissue ischemia and hypoxia. Depending on the affected organ, this can lead to various clinical manifestations. For instance, in the kidneys, microvascular thrombosis can result in acute kidney injury, while in the lungs, it can lead to acute respiratory distress syndrome (ARDS). Histologically, affected tissues may show necrosis, edema, or inflammatory infiltrates due to the ischemic damage.