Hypoglycemia, or low blood glucose levels, can also have detrimental effects on cellular function. Neurons are particularly sensitive to hypoglycemia because they rely heavily on glucose for energy. Severe hypoglycemia can result in neuronal damage and cognitive impairment. Histologically, this may be observed as neuronal loss and gliosis in brain tissue. Additionally, hypoglycemia can trigger the release of stress hormones such as adrenaline, which can cause physiological changes in various tissues.