1. Grade 1: Tumor cells have small, uniform nuclei that are round and regular. Nucleoli are inconspicuous or absent. 2. Grade 2: Nuclei are slightly larger than those in Grade 1 and show some irregularities. Nucleoli are visible but small. 3. Grade 3: Nuclei are clearly larger, irregular, and more variable in shape. Prominent nucleoli are present. 4. Grade 4: Tumor cells exhibit large, bizarre nuclei with irregular contours and prominent nucleoli. The nuclear size is significantly increased, often more than twice the diameter of normal lymphocyte nuclei.
