Addressing antigen heterogeneity requires a multifaceted approach:
1. Comprehensive Sampling: Ensuring that tissue samples are representative of the entire lesion can help in capturing the full extent of heterogeneity. 2. Advanced Diagnostic Techniques: Employing techniques like multiplex IHC and single-cell analysis can provide a more detailed understanding of antigen diversity. 3. Combination Therapies: Using a combination of therapies targeting different antigens can help overcome therapeutic resistance caused by heterogeneity. 4. Continuous Monitoring: Regular monitoring of antigen expression during treatment can help in adjusting therapeutic strategies to address emerging resistance.
