How Does Beta Thalassemia Intermedia Affect Red Blood Cells?
In beta thalassemia intermedia, red blood cells undergo significant morphological changes. Due to the imbalance in globin chain production, these cells are prone to premature destruction both within the bone marrow (ineffective erythropoiesis) and in the peripheral circulation (hemolysis). The presence of Howell-Jolly bodies—nuclear remnants within red blood cells—may also be observed, indicating a compromised spleen function or splenectomy.
