How Does APH-1 Function in the Gamma-Secretase Complex?
The gamma-secretase complex comprises four core components: presenilin, nicastrin, APH-1, and PEN-2. APH-1 serves as a stabilizing subunit, facilitating the assembly and maturation of the complex. Once assembled, the complex is responsible for the intramembrane cleavage of various substrates, including the amyloid precursor protein (APP) and Notch receptor, which are critical for neuronal function and development.
