What Are the Therapeutic Implications of Targeting APH-1?
Given its pivotal role in gamma-secretase activity, APH-1 is a potential therapeutic target for diseases like Alzheimer's. Modulating APH-1 function could help reduce the production of amyloid-beta peptides, thereby mitigating plaque formation and neuronal damage. However, therapeutic strategies must be carefully developed to avoid disrupting other essential gamma-secretase functions, such as Notch signaling, to prevent unintended side effects.
