How Do Pathological Conditions Affect the Dentate Gyrus?
Various pathological conditions can affect the dentate gyrus, such as:
- Epilepsy: Characterized by abnormal neuronal firing and synaptic reorganization, particularly in the mossy fiber pathway. - Alzheimer's Disease: Associated with amyloid-beta deposition, tau pathology, and loss of granule cells. - Depression: Often linked to reduced neurogenesis and altered synaptic plasticity.
