How do Histological Changes Affect Lung Function Tests?
Histological alterations in the lung manifest in various lung function tests. In conditions like COPD and asthma, spirometry typically shows reduced forced expiratory volume (FEV1) and a lower FEV1/FVC ratio, indicating obstructive patterns. Pulmonary fibrosis primarily affects the lung’s ability to expand, reducing total lung capacity and diffusing capacity for carbon monoxide (DLCO). These tests, combined with histological findings, provide a comprehensive assessment of lung function.
