How do chronic infections impact tissue histology?
Chronic infections can lead to significant changes in tissue histology. Persistent inflammation can result in fibrosis, where normal tissue is replaced by scar tissue, impairing its function. Granulomas, which are aggregates of immune cells formed in response to chronic infections like tuberculosis, can disrupt normal tissue architecture. Long-term infections can also lead to cellular changes, such as hyperplasia or metaplasia, which increase the risk of developing cancers. Monitoring these histological changes is crucial for managing chronic infections and preventing complications.
