antifungal agents

How Do Antifungal Agents Work?

Antifungal agents operate through different mechanisms to inhibit the growth and reproduction of fungal cells. The primary modes of action include:
1. Disruption of Cell Membrane: Agents like Azoles and Polyenes target the fungal cell membrane by inhibiting the synthesis or binding to ergosterol, an essential component of the fungal cell membrane.
2. Inhibition of Cell Wall Synthesis: Drugs such as Echinocandins inhibit the synthesis of β-glucan, a crucial component of the fungal cell wall, leading to cell lysis.
3. Disruption of DNA and RNA Synthesis: Agents like Flucytosine interfere with DNA and RNA synthesis, inhibiting fungal cell replication and growth.

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